Tag Archives: Circulatory system

Technique may help stem cells generate solid organs

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Stem cells can thrive in segments of well-vascularized tissue temporarily removed from laboratory animals, say researchers at the Stanford University School of Medicine. Once the cells have nestled into the tissue’s nooks and crannies, the so-called “bioscaffold” can then be seamlessly reconnected to the animal’s circulatory system.

The new technique neatly sidesteps a fundamental stumbling block in tissue engineering: the inability to generate solid organs from stem cells in the absence of a reliable supply of blood to the interior of the developing structure.

“Efforts to use tissue engineering to generate whole organs have largely failed,” said Geoffrey Gurtner,
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Stem cells used to clean up clogged arteries

One in every 20 Americans over the age of 50 suffers from something called, peripheral arterial disease or PAD. It can result in clogged arteries in your legs, which can cause a heart attack, if left untreated. But now there’s a new approach. Doctors using a patient’s own stem cells to clear things up. (…)

The arteries in her leg are clogged with plaque which puts her at risk for heart attack, stroke and amputation. Traditionally, doctors treat PAD with stents, angioplasties or bypasses. But now, they’re using a patient’s own stem cells to try and save her legs.

“We
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ITALY – Campobasso. Amputation Avoided Using Patient’s Own Bone Marrow Stem Cells

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A woman received a transplant of her own bone marrow stem cells, was able to avoid an amputation, and has started to walk again following an operation performed at Catholic University in Campobasso. This is one of the few such operations performed in Europe on the cardiovascular system using adult stem cells. The results were announced yesterday, about a month after the operation, and it is now clear that it will not be necessary to amputate the woman’s leg. “We can say that the operation was a complete success surgically,” said doctors that worked
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Stem Cells Used to Create New Jaw Bone

Like Samson, researchers in the field of stem cells have used the jawbone to make a point. Dr. Gordana Vunjak-Novakovic and her team at Columbia University have manipulated adult stem cells to grow one of the most difficult sections of bone to replace, the temporomandibular joint. This jawbone was created by allowing pluripotent cells harvested from marrow to grow in a scaffold that was fashioned to mimic the TMJ’s shape.

It is the first accurate and anatomically sized bone created by stem cells in a lab. Dr. Vunjak-Novakovic hopes that this new creation will serve as a proof of concept
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Patient’s Own Stem Cells Might Treat Heart Attack

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Treating a heart attack with the patients’ own bone marrow stem cells boosts blood flow within the heart and may help reduce long-term complications, a new U.S. study finds.
The study included 31 patients who underwent angioplasty and stent placement after a heart attack. Within one week of the attacks, 16 of the patients received infusions of their own bone marrow cells into the coronary artery in which a blockage had caused the event.

The 16 patients received different amounts of bone marrow stem cells — 5 million, 10 million and 15 million cells. The 15 patients in the
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