Tag Archive for 'Chronic myelogenous leukemia'

Fish oil may help cure leukemia

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A compound found in fish oil, which apparently kills leukaemia stem cells, may lead to the cure of the disease, a new study including Indian origin researcher has revealed.

The compound, delta-12-protaglandin J3, or D12-PGJ3 targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice, according to Sandeep Prabhu, associate professor of immunology and molecular toxicology in the Department of Veterinary and Medical Sciences.

He said that the compound is produced from EPA, Eicosapentaenoic Acid, an Omega-3 fatty acid found in fish and in fish oil.

“Research in the past on fatty acids has shown the health benefits of fatty acids on cardiovascular system and brain development, particularly in infants, but we have shown that some metabolites of Omega-3 have the ability to selectively kill the leukemia-causing stem cells in mice,” said Prabhu. “The important thing is that the mice were completely cured of leukemia with no relapse,” he noted.

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German Study Discovers Stem Cell ‘Silent’ Reserves

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Andreas Trumpp

Andreas Trumpp and his colleagues from the German Cancer Research Center have recently spoken about a “silent reserve” of stem cells, wondering what type of medical impact the discovery made in Heidelberg of “dormant stem cells” could have.

Usually, dormant bone marrow cells activate and multiply only in a crisis or emergency to react to serious cellular loss due to a virus or hemorrhage. When their work is done, they return to a dormant stage. This withdrawal phase keeps them protected from mutations, cellular toxins, and other dangerous substances, since the cells do not divide and are not subject to modifications or various types of aggressions.

According to the Trumpp group’s discovery, the dormant reserve can even be recruited artificially using alpha interferon proteins, as reported in Nature magazine (10.1038/nature07815).
This is an important result for various reasons. Alpha interferon is the body’s response to viral attacks on cells. Its release can be an intense, sort of SOS for the cell.

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