Damaged and aged heart tissue of older heart failure External link patients was rejuvenated by stem cells modified by scientists, according to research presented at the American Heart Association’s Basic Cardiovascular Sciences 2012 Scientific Sessions.
The study is simultaneously published in the Journal of the American College of Cardiology.
The research could one day lead to new treatments for heart failure patients, researchers said.
“Since patients with heart failure are normally elderly, their cardiac stem cells aren’t very healthy,” said Sadia Mohsin, Ph.D., one of the study authors and a post-doctoral research scholar at San Diego State University’s Heart Institute
The Jumonjd3 protein is a sort of nervous system regulator, allowing stem cells to become neural cells. Researchers from the IFOM-IEO Campus of the European Institute of Oncology (EIO) in Milan, whose studies were published in Plos One magazine discovered the regulator protein. The researchers explained that the protein is an enzyme capable of activating the stem cell genes necessary to differentiate a cell into a nervous system cell.
The result, underlined the scientists led by Giusepe Testa, “adds an important perspective to understanding the intricate mechanisms of stem cell function.” This protein could soon become “a target to improve
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SURGEONS from Southampton have developed a pioneering bone repair technique that could end the need for artificial hip replacements.
Six people have undergone the procedure which uses a their own stem cells to repair damaged hip joints. Only one operation has failed (…)
Under the procedure surgeons extract bone marrow from the back of a patients’ pelvis, then extract a layer of stem cells by spinning the marrow in a centrifuge.
The stem cells are then mixed with ground up bone donated from another patients discarded hip replacement (…)
Professor Richard Oreffo of Southampton University, one of those behind the research,