Tag Archives: Cell biology

Stem Cell Review: Tools for Drug Screening

Researchers and using stem cells as tools for disease study, drug screening, clinical trial strategy, and personalized medicine. The induced Pluripotent Stem cell (iPS) is giving us a chance to rethink the way we are developing new drugs. These iPS cells are usually created from somatic cells (such as skin), and not embryos or adult stem cells. In creating iPS from patients’ diseased cells, scientists can study the disease in vitro, looking for disease phenotypes, applying microenvironmental stress, and testing new drugs. Compared to animal model testing (e.g. mice), this represents a significant breakthrough, that can be used to
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Stem cell regenerates heart muscle

Stem cell therapy can regenerate heart muscle in primates, according to a University of Washington study.

The scientists on this and related projects are seeking way to repair hearts weakened by myocardial infarctions.

This all-too-common type of heart attack blocks a major artery and deprives heart muscle of oxygen.

People who survive a severe episode often continue their lives in poor health because their hearts no longer work properly. The researchers hope eventually to restore such failing hearts to normal function.

Their approach uses heart cells created from human embryonic stem cells

The researchers tested the possibility of producing enough of these cardiac muscle
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STEM CELLS BATTLE FOR SPACE

The body is a battle zone. Cells constantly compete with one another for space and dominance. Though the manner in which some cells win this competition is well known to be the survival of the fittest, how stem cells duke it out for space and survival is not as clear. A study on fruit flies published in the October 2 issue of Science by Johns Hopkins researchers describes how stem cells win this battle by literally sticking around.

“Our work exemplifies how one signal coordinately maintains two types of stem cells in a single niche, or microenvironment,” says Erika Matunis,
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Transplants: human-pig embryos from stem cells

Scientists have for the first time grown embryos that contain a combination of pig and human stem cells, in a step toward one day growing transplantable organs, a study said on Thursday.

However, the research remains at a very early stage and proved more difficult than expected, the researchers reported in the peer-reviewed journal Cell.

“This is an important first step,” said lead investigator Juan Carlos Izpisua Belmonte, a professor in the Salk Institute of Biological Studies’ Gene Expression Laboratory.

“The ultimate goal is to grow functional and transplantable tissue or organs, but we are far away from that.”

Scientists implanted adult human
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Umbilical Stem Cells May Help Recover Lost Vision for Those With Corneal Disease

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CINCINNATI—New research from the University of Cincinnati may help in the recovery of lost vision for patients with corneal scarring.

Winston Whei-Yang Kao, PhD, professor of ophthalmology, along with other researchers in UC’s ophthalmology department found that transplanting human umbilical mesenchymal stem cells into mouse models that lack the protein lumican restored the transparency of cloudy and thin corneas.

Mesenchymal stem cells are “multi-potent” stem cells that can differentiate into a variety of cell types.

These findings are being presented Dec. 8 in San Diego at the 49th Annual Meeting of the American Society of Cell Biology.

“Corneal transplantation is currently
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