A spun 3-D scaffold of nanofibers did a better job of producing larger quantities of and a more durable type of the cartilage protein than flat, 2-D sheets of fibers did.
Johns Hopkins tissue engineers have used tiny, artificial fiber scaffolds thousands of times smaller than a human hair to help coax stem cells into developing into cartilage, the shock-absorbing lining of elbows and knees that often wears thin from injury or age.
Reporting online June 4 in the Proceedings of the National Academy of Sciences, investigators say they have produced an important component of cartilage in both laboratory
The study Sun has been working on in Dr. Farshid Guilak’s laboratory has found that engineered cartilage constructed from a particular type of stem cell integrate well with host cartilage, but not necessarily in a uniform way.
Sun was one of about thirty biomedical engineering students who presented at the department’s graduation with distinction reception on April 26. Other students have been working on exciting projects in optic imaging of tumors, synthetic biology, and deep brain stimulation, among other topics.
Sun’s project focused on how induced pluripotent stem cells can be used to study cartilage regeneration and repair.
“You can make liver. You can make pancreas. You can make bone. Therefore you can make neuro cells. You can make heart cells,” said Dr. Robert Carpenter
Yes, he said make a liver make a heart. From what? Stem cells from your teeth.
“We recently discovered that adult stem cells that don’t have the controversy related to it like embryonic cells have the ability to regenerate and treat a number of illnesses and injuries,” Carpenter said.
Stem cells are being studied to affect other disease like diabetes, kidney problems; liver problems even Parkinson’s disease. It’s in human clinical trials, and
Osteoarthritis is a very common joint disorder. Due to age and normal wear and tear on the joints, the cartilage that protects the joint begins to break down, causing the bone to rub together which leads to pain and swelling in the joints. There is no cure for osteoarthritis, and up until now, many patients feel that surgery is their only option to manage the symptoms.
However, recently orthopaedic investigators have been studying the effects of periodic injections to the knee of stem cells from synovium, a thin membrane covering the inside of the joint. Nobutake Ozeki from Tokyo Medical
Johns Hopkins tissue engineers have used tiny artificial fiber scaffolds thousands of times smaller than a human hair to help coax stem cells into developing into cartilage, the shock-absorbing lining of elbows and knees that often wears thin from injury or age.
Reporting online June 4 in the Proceedings of the National Academy of Sciences, investigators say they have produced an important component of cartilage in both laboratory and animal models. While the findings are still years away from use in people, the researchers say the results hold promise for devising new techniques to help the millions who