Making a breakthrough in the battle against breast cancer, scientists have used a combination of drugs to target cancer stem cells that cause the disease to spread.
Current treatments kill only the surface cells in a breast tumour, but scientists now say they can destroy the root, the Mirror reported.
They hope that the findings, revealed ahead of World Cancer Day, can be used to help women with advanced and aggressive cancers. Targeting cancer stem cells takes us a step closer to better clinical options for those with the disease, said Dr Rob Clarke, of Manchester University.
Sarcomas are cancers of connective tissues, such as bone, adipose and cartilage, and are thought to arise from the aberrant development of the mesenchyme. As such, mesenchymal stem cells are thought to be the cell of origin for sarcomas. Genetic or epigenetic lesions at particular points during the differentiation of a mesenchymal stem cell into its terminal mesenchymal cell type are able to give rise to specific subtypes of sarcomas.
Recently, a number of reports have identified elevated expression of the human Piwi homolog–called Hiwi–in a variety of human cancers, including gastric cancer, pancreatic cancer, gliomas and, most relevant for
Two scientists at the Fred Hutchinson Cancer Research Center in Seattle have been awarded $16.7 million for stem cell research projects.
Dr. Irwin Bernstein and Beverly Torok-Storb received the federal funding from the National Heart, Lung and Blood Institute. Their award is part of a $170 million effort divided among 18 scientific teams.
Torok-Storb will work with Dr. Mortimer Poncz of Children’s Hospital of Philadelphia to develop molecular and cell-based therapies for a range of blood diseases, using an $8.2 million grant.
Bernstein will work with Edward Morrisey of the University of Pennsylvania to study how biochemical reactions inside cells affect cell
Stem Cell Research Provides Help for Breast Reconstruction
Irene MacKenzie had a lumpectomy for her early stage breast cancer leaving her with a hollow in her breast. The lumpectomy took care of the cancer, but what about her breast? Well, Irene was the first person in Britain to reap the benefits of Stem Cell [...]
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In a genetic engineering breakthrough that could help everyone from bed-ridden patients to elite athletes, a team of American researchers—including 2007 Nobel Prize winner Mario R. Capecchi—have created a “switch” that allows mutations or light signals to be turned on in muscle stem cells to monitor muscle regeneration in a living mammal. For humans, this work could lead to a genetic switch, or drug, that allows people to grow new muscle cells to replace those that are damaged, worn out, or not working for other reasons (e.g., muscular dystrophy). In addition, this same discovery also gives researchers