Researchers have identified a way to enhance regrowth of human corneal tissue to restore vision, using a molecule that acts as a marker for hard-to-find limbal stem cells.
This work, a collaboration among the Harvard-affiliated Massachusetts Eye and Ear/Schepens Eye Research Institute, Boston Children’s Hospital, Brigham and Women’s Hospital, and the VA Boston Healthcare System, holds promise for burn patients, victims of chemical injury, and others with damaging eye diseases.
The research, published this week in the journal Nature,is also one of the first examples of constructing a tissue from an adult-derived human stem cell.
Limbal stem cells reside in the eye’s
A sophisticated imaging system, multi-isotope imaging mass spectrometry (MIMS), demonstrates cell division in the adult mammalian heart. Researchers were surprised to find that new heart muscle cells primarily arose from existing heart muscle cells, rather than stem cells.
Recent research has shown that there are new cells that develop in the heart, but how these cardiac cells are born and how frequently they are generated remains unclear.
In a study from Harvard-affiliated Brigham and Women’s Hospital (BWH), researchers used a novel method to identify the new heart cells and describe their origins.
The research was published today in Nature.
“The question about how
Piero Anversa, Italian scientist and director of regenerative medicine at the Brigham and Women’s Hospital of Harvard University in Boston is ready to perform the first biological by-pass in history. This evening in Milan during a meeting called ‘Futuro della Sanita’ (The Future of Health), Anversa explained that he has identified human coronary stem cells able to develop into coronary artery tissue.
He said, “My dream is for someone to have a heart attack, come to the hospital, and return home healthy.” For that to occur, it will be necessary to reproduce muscle and the large coronary vessels.