Making a breakthrough in the battle against breast cancer, scientists have used a combination of drugs to target cancer stem cells that cause the disease to spread.
Current treatments kill only the surface cells in a breast tumour, but scientists now say they can destroy the root, the Mirror reported.
They hope that the findings, revealed ahead of World Cancer Day, can be used to help women with advanced and aggressive cancers. Targeting cancer stem cells takes us a step closer to better clinical options for those with the disease, said Dr Rob Clarke, of Manchester University.
Madison, Wisconsin – More than a decade of laboratory research at the University of Wisconsin has proven that a single chemical compound may both detect and treat malignant tumors and certain cancer stem cells.
In three posters presented at the annual meeting of the American Association for Cancer Research (AACR) in Chicago, March 31-April 4, UW-Madison researchers describe exciting advances involving CLR1404, described as a “diapeutic” agent that can both image and destroy a wide range of malignant tumors and the one type of cancer stem cells examined so far.
The presentations are based on basic research in the lab of
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British team pioneers reconstruction technique using enriched tissue
A remarkable reconstruction technique is being trialled by British surgeons, who are harvesting stem-cell-enriched fat from women’s bodies to plug the dip often left by breast cancer operations.
The procedure appears to restore the softness and suppleness of breast tissues, undoing the damage frequently caused by lumpectomy and radiotherapy. Early signs indicate that it also eases the considerable pain with which patients are often left after treatment.
More than 31,000 women a year in Britain with early-stage breast cancer undergo operations in which just the lump and a healthy margin of tissue
LA JOLLA—By carefully controlling the levels of two proteins, researchers at the Salk Institute have discovered how to keep mammary stem cells—those that can form breast tissue—alive and functioning in the lab. The new ability to propagate mammary stem cells is allowing them to study both breast development and the formation of breast cancers.
“What we’ve shown is that we can take these cells out of a mouse and study them and regulate them in the laboratory by providing them with a specific factor,” says Peter C. Gray, a staff scientist in Salk’s Clayton Foundation Laboratories for Peptide Biology, who
December 4, 2009- Working with mice, scientists at Johns Hopkins publishing in the December issue of Neoplasia have shown that a protein made by a gene called “Twist” may be the proverbial red flag that can accurately distinguish stem cells that drive aggressive, metastatic breast cancer from other breast cancer cells.
Building on recent work suggesting that it is a relatively rare subgroup of stem cells in breast tumors that drives breast cancer, scientists have surmised that this subgroup of cells must have some very distinctive qualities and characteristics.