Investigators at the Stanford University School of Medicine have devised a way to monitor neural stem cells after they’ve been transplanted into the brain.
The scientists were able to determine not only whether the stem cells transplanted into living animals survived but whether they matured into nerve cells, integrated into targeted brain circuits and, most important, were firing on cue and igniting activity in downstream nerve circuits.
In 2010, L V Prasad Eye Institute (LVPEI) moved away from culturing corneal stem cells in a petri-dish in the laboratory to directly culturing and expanding them on the patient’s eye.
This ingenuous technique was termed Simple Limbal Epithelial Transplantation (SLET) to contrast it from the radical tissue transplants and complex culture techniques that were the standard of care at that time.
SLET completely eliminates the need for laboratory based processing thereby making it possible to be executed by any well trained surgeon anywhere (…)
A pilot clinical trial was done on a small sample size including 125 patients, 65 adults and 60
(…) The investigators looked at two types of brain cells: adult neural stem cells, responsible for maintaining supplies of neurons and their supporting cells, and forebrain neurons, vital for performing complex cognitive tasks.
In The EMBO Journal, they reported that NAD (Nicotinamide adenine dinucleotide) levels decreased with age in the mouse hippocampus, a vital region of the brain for cognition. The researchers then used genetic techniques to find out what would happen when NAD manufacturing is turned off in the adult neural stem cells of the mouse brain.
“Neural stem cells are very metabolically expensive, so you might expect them to be
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Memorial Hermann-Texas Medical Center in Houston announced this morning it has done the nation’s first stem cell transplant to successfully treat a stroke patient.
The patient came to the hospital last Wednesday, too late to receive clot-busting drugs to treat the stroke, according to a news release about the procedure. So doctors decided to try a therapy they are investigating as part of a clinical trial with the University of Texas Medical School at Houston: using stem cells from the patient’s own bone marrow. The adult stem cells — not controversial embryonic stem cells — came from marrow
For years, researchers seeking new therapies for traumatic brain injury have been tantalized by the results of animal experiments with stem cells. In numerous studies, stem cell implantation has substantially improved brain function in experimental animals with brain trauma. But just how these improvements occur has remained a mystery.
Now, an important part of this puzzle has been pieced together by researchers at the University of Texas Medical Branch at Galveston. In experiments with both laboratory rats and an apparatus that enabled them to simulate the impact of trauma on human neurons, they identified key molecular mechanisms by which implanted