Leukemia, the most common form of childhood cancer, affects the blood-forming cells in the bone marrow. It is often treated with stem cell transplants that replace the patient’s bone marrow cells with stem cells donated by a healthy individual. Successful transplant depends on finding a donor who is a close genetic match to the patient. That’s a particular challenge for patients from racial and ethnic minority groups, who may die while waiting for a matching donor.
But a mostly-untapped source of genetically diverse stem cells is right under our noses: Blood left in the umbilical cord after a baby is
Mohammad Reza Zafarghandi
Following the success of Iranian scientists in using stem cells to treat vascular occlusion and critical limb ischemia in the lower extremities, Press TV has conducted an interview with research team leader Mohammad Reza Zafarghandi.
Dr. Zafarghandi is a professor of vascular surgery in Tehran University of medical Sciences and the head of the vascular surgery and trauma department of Sina Hospital.
Press TV: According to news reports, you have successfully treated 12 patients suffering from vascular occlusion using stem cells. Could you tell us more about it?
Zafarghandi: Critical limb ischemia (CLI) results from severe occlusive disease that
UCLA researchers have discovered a type of cell that is the “missing link” between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.
The research was done using human bone marrow, which contains all the stem cells that produce blood during post-natal life.
“We felt it was especially important to do these studies using human bone marrow, as most research into the development of the immune system has used
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Russian scientists started clinical trials of treating false joints by means of demineralized bone matrix with introduced mesenchymal stem cells of a patient.
False joints often occur as a complication during fractures of long bones, when splinters do not adhere, and cartilage layer forms between them. This layer is called false joint, and in this case, additional surgery is required to help a bone to heal.
Modern surgeons fight this problem with bone transplants, but bone recovery takes about one year. Possible solution is transplantation of mesenchymal stem cells of bone marrow, which can turn into various cells, including
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Stem cells can thrive in segments of well-vascularized tissue temporarily removed from laboratory animals, say researchers at the Stanford University School of Medicine. Once the cells have nestled into the tissue’s nooks and crannies, the so-called “bioscaffold” can then be seamlessly reconnected to the animal’s circulatory system.
The new technique neatly sidesteps a fundamental stumbling block in tissue engineering: the inability to generate solid organs from stem cells in the absence of a reliable supply of blood to the interior of the developing structure.
“Efforts to use tissue engineering to generate whole organs have largely failed,” said Geoffrey Gurtner,