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Russian scientists started clinical trials of treating false joints by means of demineralized bone matrix with introduced mesenchymal stem cells of a patient.
False joints often occur as a complication during fractures of long bones, when splinters do not adhere, and cartilage layer forms between them. This layer is called false joint, and in this case, additional surgery is required to help a bone to heal.
Modern surgeons fight this problem with bone transplants, but bone recovery takes about one year. Possible solution is transplantation of mesenchymal stem cells of bone marrow, which can turn into various cells, including
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Stem cells can thrive in segments of well-vascularized tissue temporarily removed from laboratory animals, say researchers at the Stanford University School of Medicine. Once the cells have nestled into the tissue’s nooks and crannies, the so-called “bioscaffold” can then be seamlessly reconnected to the animal’s circulatory system.
The new technique neatly sidesteps a fundamental stumbling block in tissue engineering: the inability to generate solid organs from stem cells in the absence of a reliable supply of blood to the interior of the developing structure.
“Efforts to use tissue engineering to generate whole organs have largely failed,” said Geoffrey Gurtner,
Some stem cells can lay dormant for more than two weeks in a dead person and then be revived to divide into new, functioning cells, scientists in France said.
The research, published in the journal Nature Communications, unlocks further knowledge about the versatility of these cells, touted as a future source to replenish damaged tissue.
“Remarkably, skeletal muscle stem cells can survive for 17 days in humans and 16 days in mice, post mortem well beyond the 1-2 days currently thought,” they said in a statement.
The stem cells retained their ability to differentiate into perfectly functioning muscle cells, they found.
A new report brings bioengineered organs a step closer, as scientists from Stanford and New York University Langone Medical Center describe how they were able to use a “scaffolding” material extracted from the groin area of mice on which stem cells from blood, fat, and bone marrow grew. This advance clears two major hurdles to bioengineered replacement organs, namely a matrix on which stem cells can form a 3-dimensional organ and transplant rejection.
DaVinci Biosciences LLC, of Costa Mesa, CA, announced today the presentation of their safety and feasibility study demonstrating the administration of autologous bone marrow derived stem cells for the treatment of acute and chronic spinal cord injury at Neuroscience 2009, Society for Neuroscience’s 39th Annual Meeting, to be held at McCormick Convention Center in Chicago, IL. Rafael Gonzalez, Ph.D., Director of Research and Development for DaVinci Biosciences LLC will present the work during the conference on October 20, 2009 and be available to answer questions regarding the study, following his presentation.
“We are excited to share the findings