Tag Archives: Bone marrow

Boy ‘leading revolution’ in stem cell surgery for children

Ciaran Finn-Lynch, who became the first child in the world to undergo a groundbreaking trachea transplant in March this year, is set to return home to Northern Ireland.

Ciaran underwent the transplant, which involved the removal of his own trachea replaced by a donor windpipe, at Great Ormond Street Hospital. Doctors then used Ciaran’s own stem cells from inside his body to build up the donor windpipe and ensure the organ was not rejected.

Four weeks ago, doctors were able to describe the transplant as a success for the first time after proving vascular supply had returned to
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Recovering From Radiation and Chemotherapy

Researchers at the University of California, San Diego School of Medicine report that a protein called beta-catenin plays a critical, and previously unappreciated, role in promoting recovery of stricken hematopoietic stem cells after radiation exposure.

The findings, published in the May 1 issue of Genes and Development, provide a new understanding of how radiation impacts cellular and molecular processes, but perhaps more importantly, they suggest new possibilities for improving hematopoietic stem cell regeneration in the bone marrow following cancer radiation treatment.

Ionizing radiation exposure – accidental or deliberate – can be fatal due to widespread destruction of hematopoietic stem cells, the
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Indian doctors cure thalassaemia using stem cells

When others of her age played with dolls, eight-year-old Thamirabharani was taking blood transfusions.
Born with thalassaemia, she has, however, found hope. She was detected with the disease when she was a year and a half and has been undergoing regular blood transfusions since.

Haematologist Revathy Raj and his team from Apollo Gleneagles hospital in Chennai gave a new lease of life to the little girl from Coimbatore through stem cell transplantation. Doctors said she is now fully cured and has not needed a single transfusion since March.

Doctors claimed this is the first success story in India using the stem cells
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Hysterectomies a stem cell source

Discarded fallopian tubes from hysterectomies could be a good source of donor stem cells, say researchers.
Work shows they are an abundant source of the immature cells that have the potential to become a variety of the body’s tissues, like muscle and bone.

The discovery offers another “ethical” route to creating stem cell treatments for diseases like arthritis without using embryos.
The findings are published in The Journal of Translational Medicine.
Experts have already shown that getting mesenchymal stem cells from umbilical cords, menstrual blood, teeth and fat tissue is viable.

Discarded tissue

The latest work by a Brazilian team from the University of São
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Blood Vessel Cells Are Key to Growing Unlimited Amounts of Adult Stem Cells

Howard Hughes Medical Institute (HHMI) scientists have discovered that endothelial cells, the building blocks of the vascular system, keep blood stem cells dividing healthily in a lab dish much longer and more effectively than previous methods of growing the cells. The new advance dramatically improves scientists’ ability to manufacture large quantities of authentic adult blood stem cells, which may help revolutionize the field of bone marrow transplantation.

Shahin Rafii, an HHMI investigator at Weill Cornell Medical College in New York City, and his colleagues report on the development of an endothelial cell platform that supports self-renewal of the blood stem
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