Gregg Semenza, M.D., Ph.D.
Blood vessel blockage, a common condition in old age or diabetes, leads to low blood flow and results in low oxygen, which can kill cells and tissues. Such blockages can require amputation resulting in loss of limbs. Now, using mice as their model, researchers at Johns Hopkins have developed therapies that increase blood flow, improve movement and decrease tissue death and the need for amputation. The findings, published online last week in the early edition of the Proceedings of the National Academy of Sciences, hold promise for developing clinical therapies.
“In a young, healthy individual, hypoxia
(…) Three months ago the world’s first cosmetic stem-cell facelift was carried out on Pauline Wills, 55, an office manager from South London, by Dr Aamer Khan from the Harley Street Medical Skin Clinic. It cost £7,500, took nearly six hours under local anaesthetic and Pauline had the added bonus of losing an inch from her tummy.
And because the procedure uses the body’s own stem cells – which makes it a living tissue graft – you grow into your own facelift during the six months afterwards (…)
Stem cells are present throughout the body and one of their functions is
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Scientists have for the first time succeeded in extracting vital stem cells from sections of vein removed for heart bypass surgery. Researchers funded by the British Heart Foundation (BHF) found that these stem cells can stimulate new blood vessels to grow, which could potentially help repair damaged heart muscle after a heart attack.
The research, by Paolo Madeddu, Professor of Experimental Cardiovascluar Medicine and his team in the Bristol Heart Institute (BHI) at the University of Bristol, is published in the leading journal Circulation.
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A research group at Imperial College London has designed a new treatment able to significantly improve the body’s capacity to repair damage caused by a heart attack or bone fracture. The new therapy, described in Cell Stem Cell, ‘fools’ the spinal cord inducing it to ’overproduce’ stem cells which repair damaged tissues in the body. Researchers hope to test the treatment on animals by the end of the year. If testing is successful, the next step will be to experiment on human beings attempting to induce them to use their own stem cells
The mesenchymal stem cells found in the bone marrow can give rise to bone, fat, and muscle tissue, and have been used in hundreds of clinical trials for tissue repair.
Unfortunately, the results of these trials have been underwhelming, the main problem being that these stem cells do not stick around in the body long enough to benefit the patient.
Researchers have now found that transplanting mesenchymal stem cells along with blood vessel-forming cells naturally found in circulation improves results.