MIT engineers have boosted stem cells’ ability to regenerate vascular tissue (such as blood vessels) by equipping them with genes that produce extra growth factors (naturally occurring compounds that stimulate tissue growth). In a study in mice, the researchers found that the stem cells successfully generated blood vessels near the site of an injury, allowing damaged tissue to survive.
Why it matters: Stem cells hold great potential as a way to promote tissue regeneration. However, this approach has been limited because stem cells don’t produce enough growth factors after transplantation. The researchers’ new super-charged stem cells could be used to
Mohammad Reza Zafarghandi
Following the success of Iranian scientists in using stem cells to treat vascular occlusion and critical limb ischemia in the lower extremities, Press TV has conducted an interview with research team leader Mohammad Reza Zafarghandi.
Dr. Zafarghandi is a professor of vascular surgery in Tehran University of medical Sciences and the head of the vascular surgery and trauma department of Sina Hospital.
Press TV: According to news reports, you have successfully treated 12 patients suffering from vascular occlusion using stem cells. Could you tell us more about it?
Zafarghandi: Critical limb ischemia (CLI) results from severe occlusive disease that
MIAMI, Fla. (Ivanhoe Newswire) — Some are calling it the next big frontier in cardiac treatment — injecting stem cells to regenerate the heart. But the experimental procedure means major surgery. Doctors are opening the door for heart patients who want to test the benefits of stem cells — without an operation.
One heart attack behind him, Max Eaton is now struggling with heart failure. He’s hoping stem cells are the answer to heal his ailing heart. “I happened to run into this article, which was the second or third time I heard about this stem cell research, and decided
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A technique that combines nanotechnology with adult stem cells appears to destroy atherosclerotic plaque and rejuvenate the arteries, according to a study reported at the American Heart Association‘s Basic Cardiovascular Sciences 2010 Scientific Sessions – Technological and Conceptual Advances in Cardiovascular Disease.
In the study, nanoparticles (microscopic particles with at least one dimension less than 80 nm) were infused into the heart of pigs along with adult stem cells. After the nanoparticles were heated by laser light, they burned away arterial plaque. However, nanoparticles were less effective at eliminating plaque if not combined with adult stem cells.
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Stem cells can thrive in segments of well-vascularized tissue temporarily removed from laboratory animals, say researchers at the Stanford University School of Medicine. Once the cells have nestled into the tissue’s nooks and crannies, the so-called “bioscaffold” can then be seamlessly reconnected to the animal’s circulatory system.
The new technique neatly sidesteps a fundamental stumbling block in tissue engineering: the inability to generate solid organs from stem cells in the absence of a reliable supply of blood to the interior of the developing structure.
“Efforts to use tissue engineering to generate whole organs have largely failed,” said Geoffrey Gurtner,