What are the differences between embryonic, adult and induced pluripotent stem cells? Where do the experts expect the next medical application will be for stem cells? Do stem cells promote regeneration? How are cell types interacting? How can induced pluripotent stem (iPS) cells revolutionize drug discovery? Can cell therapies be made into a viable business? How close are we to finding the right business model? Are investors interested in stem cells today? What is the political and ethical landscape like now that the Obama administration has taken over the White House?
This is the Episode 1 of the Stem Cell
Cells grown in culture are not alone: They are constantly communicating with one another by sending signals through their culture media that are picked up and transmitted by other cells in the media. When thousands of cells are cultured together in a dish, there are hundreds of thousands of these signals present every minute, all competing to be heard.
Scientists trying to direct cells to do useful things — like causing stem cells to turn into neurons or heart cells — typically try to overcome these signals by adding their own exogenous factors. These exogenous factors are often added at
A team of researchers at the UC Davis Institute for Regenerative Cures has developed a technique for using stem cells to deliver therapy that specifically targets the genetic abnormality found in Huntington’s disease, a hereditary brain disorder that causes progressive uncontrolled movements, dementia and death. The findings, now available online in the journal Molecular and Cellular Neuroscience, suggest a promising approach that might block the disease from advancing.
“For the first time, we have been able to successfully deliver inhibitory RNA sequences from stem cells directly into neurons, significantly decreasing the synthesis of the abnormal huntingtin protein,” said Jan A.
Researchers from the Center for Stem Cell Biology and Regenerative Medicine and the Department of Medicine at Thomas Jefferson University claim that a gene shown to play a role in the aging process appears to play a role in the regulation of the differentiation of embryonic stem cells.
In the study, published online in the journal Aging Cell, the researchers identified a protein interaction that controls the silencing of Oct4, a key transcription factor that is critical to ensuring that embryonic stem cells remain pluripotent. The protein, WRNp, is the product of a gene associated with Werner syndrome, an autosomal
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Health Minister Nelson Bascome on January 28 said his Ministry will not be doing anything about Bermuda’s lack of adult stem cell regulations at this stage — but pledged to ensure good practices would be in place before a stem cell clinic opens.
At a news conference yesterday about a revised Bermuda Health Council, Mr. Bascome was questioned about his position on the Brown-Darrell Clinic, which is scheduled to open early this year.
When asked specifically about introducing legislation to effectively monitor and regulate the clinic, the Minister said nothing had come across his desk.
He said: “Anything that has