A team of researchers at the UC Davis Institute for Regenerative Cures has developed a technique for using stem cells to deliver therapy that specifically targets the genetic abnormality found in Huntington’s disease, a hereditary brain disorder that causes progressive uncontrolled movements, dementia and death. The findings, now available online in the journal Molecular and Cellular Neuroscience, suggest a promising approach that might block the disease from advancing.
“For the first time, we have been able to successfully deliver inhibitory RNA sequences from stem cells directly into neurons, significantly decreasing the synthesis of the abnormal huntingtin protein,” said Jan A.
Researchers from the Center for Stem Cell Biology and Regenerative Medicine and the Department of Medicine at Thomas Jefferson University claim that a gene shown to play a role in the aging process appears to play a role in the regulation of the differentiation of embryonic stem cells.
In the study, published online in the journal Aging Cell, the researchers identified a protein interaction that controls the silencing of Oct4, a key transcription factor that is critical to ensuring that embryonic stem cells remain pluripotent. The protein, WRNp, is the product of a gene associated with Werner syndrome, an autosomal
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Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors. However, the low efficiency and slow kinetics of the reprogramming process have hampered progress with this technology. Here we report that a natural compound, vitamin C (Vc), enhances iPSC generation from both mouse and human somatic cells. Vc acts at least in part by alleviating cell senescence, a recently identified roadblock for reprogramming.
In addition, Vc accelerates gene expression changes and promotes the transition of pre-iPSC colonies to a fully reprogrammed state. Our results therefore highlight a straightforward method for improving the speed and
Stem Cell Research Brings About Another Miracle
Korean doctors have apparently regrown a patient’s jawbone using the patient’s own Adult Stem Cells in yet another amazing miracle that Adult Stem Cell research has brought us.
An 18 year old Korean boy who had to have most of his jawbone and his teeth removed due to a tumor […]
The Jumonjd3 protein is a sort of nervous system regulator, allowing stem cells to become neural cells. Researchers from the IFOM-IEO Campus of the European Institute of Oncology (EIO) in Milan, whose studies were published in Plos One magazine discovered the regulator protein. The researchers explained that the protein is an enzyme capable of activating the stem cell genes necessary to differentiate a cell into a nervous system cell.
The result, underlined the scientists led by Giusepe Testa, “adds an important perspective to understanding the intricate mechanisms of stem cell function.” This protein could soon become “a target to improve