“Latest Stem Cells News”

The U.S. government approved the first 13 batches of human embryonic stem cells on Wednesday, enabling researchers using them to get millions of dollars in federal funding as promised by President Barack Obama in March.

“Today we are announcing the approval of the first 13 stem cell lines,” Collins told reporters in a telephone briefing.

In March, Obama lifted restrictions on human embryonic stem cell research imposed by his predecessor, George W. Bush.

He could not lift a restriction set by Congress, called the Dickey-Wicker amendment, that forbids the use of federal money to make the stem cells, which require destruction of a human embryo. But the decision made it possible for researchers to use federal funds to work with cells that others have made.

A year after President Barack Obama issued a landmark executive order to remove eight years of limitations on U.S. federal funding of stem cell research, the WiCell Research Institute has expanded the number of cell lines available through its WISC Bank (Wisconsin International Stem Cell) to 33.

WiCell, host of the former National Stem Cell Bank (NSCB) for five years under a contract from the National Institutes of Health (NIH), has transitioned the distribution of all of the 20 human embryonic stem cell (hESC) lines formerly available through the NSCB to its own stem cell bank. The bank also continues to carry its previously banked seven induced pluripotent stem (iPS) cell lines and six genetically modified hES cell lines.

Kidney stem cells, according to some experts, could be able to repair kidney damage if used properly. The first researchers to identify the cells were scientists at the University of Florence, who published an article recently in the Journal of the American Society of Nephrology. Giuseppe Remuzzi, the head of the Nephrology and Dialysis division of the United Hospitals of Bergamo recently spoke about their potential in Milan at the World Nephrology Congress.

“The truth about stem cells,” explained the expert, “ is what US President Barack Obama pointed out when he announced the repeal of laws banning the federal financing of embryonic stem cell studies. They are promising, but there is still a lot of work to do. Currently, these cells treat very few diseases. We must study them and compare the various types.”

Many scientists, continued Remuzzi, believe in them, although the results are few and mostly have been obtained in vitro. “Everyone’s dream is to repair organs with stem cells.” There are good possibilities for kidneys, he added. “Since stem cells could be responsible for a regeneration process observed in animals treated with Ace-inhibitor drugs, which delay the progression of kidney diseases. The idea is that these cells have an innate ability to repair damages, which, through the use of drugs, can be directed and sustained, with good results.”

“For the first time, taxpayer money will be used to kill human beings in the embryonic state in order to harvest stem cells,” wrote the Osservatore Romano newspaper, which underlined how this is the result of new guidelines “after President Barack Obama overturned a decision by the Bush administration banning publically funded stem cell research”.

The Vatican newspaper cited the website of the Episcopal Conference of the United States which said “this is a new chapter in the division between biomedical research and its necessary ethical basis, the respect for human life at all stages.” “Although an embryo risks being abandoned by its parents in a fertility clinic, this does not authorize the government and researchers to kill a human being, much less give them the right to force us to finance this destructive project,” pointed out the website cited by the Observer, which also underlined the progress by researchers with non-embryonic stem cells.

According to the American bishops, embryonic stem cells have been given lots of attention, but in reality adult cells are more important for research. The Observer also cited the Archbishop of Denver, Monsignor Charles Joseph Chaput, who said “religious convictions must play an important role in public debate” and “the United States must remain faithful to its founding principles”.

The Archbishop of Denver told the Osservatore that “public life in America cannot function if we keep our religious beliefs in the closet. America does not need to be a Christian country, but it cannot survive if it is not open to acceptance, solidarity, and faith”. Monsignor Chaput also told the Osservatore about his “perplexity regarding US President Barack Obama’s inaugural address where he spoke about the role of science in society.

Science,” he concluded, “must serve human dignity, and can never be above or beyond God’s moral judgment. Jews, Protestants, Catholics, and other religions have something precious to protect: faith in God, and we must defend it with reciprocal respect and without alibis, excuses, or conflicts”. The Osservatore also spoke about the outcry against Obama at Notre Dame due to an honorary degree he received at the catholic university, which “was expected”. “But from the podium, set up in the basketball arena, the president asked Americans of all religions and ideologies to ‘take part in a common effort’ to reduce the number of abortions”.

“Search for a common ground is what seems to be the path chosen by the President of the United States to face the delicate issue of abortion,” reported the Vatican newspaper. “Aside from the heated debates during the electoral campaign, Obama confirmed what he said at his 100 days press conference, when he said that passing abortion legislation is not a priority of his administration.”

The South Korean bioethics committee has lifted a ban on human stem cell research. The decision will now allow for work on human embryonic stem cells to resume after being interrupted three years ago following the scandal involving Hwang Woo-suk, the false “pioneer of human cloning”. The veterinarian, a national hero at the time, fell from grace after the international scientific community and the University of Seoul uncovered that results from his research on embryonic stem cells were falsified in the laboratory to give the impression that his group was successful in cloning healthy cells from cells affected by incurable diseases.

The lifting of the research ban, explained the bioethics committee, involves a hospital in Seoul (Cha General Hospital), which will resume research under four conditions: written approval from women donating eggs (only those from aborted fetuses will be used); the use of laboratory animals to reduce the use of these eggs to a minimum; instituting a surveillance committee to avoid abuses; the names of the studies must not refer to words or meanings that could “feed false hopes”, including mentioning “cure for Parkinson’s”. The decision to lift the ban must receive authorization from the Health Ministry, and in all likelihood, it will not be rejected.

South Korea seems to be following the policy decisions regarding bioethics of the American administration. Among the steps taken by US President Barack Obama, is also the decision to resume financing for human stem cell research with an initial allocation of one billion dollars. “The decision will restart research,” said Chung Hyung-Min, who pointed out that such studies “have been performed by English scientists and other countries” but until now “there have not scored any successes”.

Embryonic stem cell research has sparked a heated worldwide debate involving ethics, science, and the right to life. The position of the Catholic Church has always been that it considers embryos as human lives. In May of 2008, bishops confirmed strongly condemned the revisions of the law on bioethics approved by Parliament, which allow for those who accept to participate in cloning experiments to be eligible for “reimbursements of their expenses”.

Sierra Fedelem may look like any other 20-month-old, but her parents are doing everything they can to make sure her life is just like that of any other healthy human being.
Stem cell research has stirred quite the controversy in the United States, and though the current administration’s recent policy reversal on the issue could open the markets to treatments and commercialization, it’s still an option unavailable for American patients, like Sierra, unless they’re willing to travel across the world.

“The first time the neurologist said, ‘No, you don’t realize it, she’s never going to be able to walk, talk and see, and she’s always going to be at the mental level of a 4-month-old’,” Rosetta Fedelem said. “We were just shocked.”
The Fedelems hadn’t realized the extent of the brain damage Sierra suffered during birth.

“We said ‘We’re not going to stop, we’re going to start doing as much as you can for her’,” Rosetta said. “So we started praying and researching.”
Their research landed them in China, where Sierra received several treatments of adult stem cells extracted from somebody else’s umbilical cord. Adult stem cells differ from embryonic stem cells, in that they can be retrieved from adult organs or tissue.

While leading U.S. experts say the possibilities are far-reaching, the quality of overseas studies remains uncertain.
“It’s very hard to tell which is a good place, and which is not,” Texas A&M Health Science Center College of Medicine Institute for Regenerative Medicine Director Dr. Darwin Prockup said. “But of course, patients get to be desperate, and you can’t blame them for trying.”

Dr. Prockup said better adult stem cell treatments in the United States are coming. In March, President Barack Obama signed an executive order, reversing Bush administration policy, to allow scientists to continue stem cell research on ongoing projects. The results of the research will determine when the United States will open its doors to treatment.
“Of course there’s always danger with any therapy, so you have to be very careful, there’s always a risk-benefit you have to weigh carefully,” Prockup said. “That’s done in good medical centers. That’s why we’re a little slower.”

The Fedelems said they did weigh the pros and cons.
“I don’t accept new things easily, but when there’s enough evidence of results, I’m willing to try them,” Jason said. “And that’s exactly what happened here.”

In the three weeks they’ve been back from China, Sierra can sit up on her own for a few seconds, do an army crawl, and stand up for more than twice the amount of time she could before. Plus, her parents say she’s more alert and vocal.
Rosetta and Jason say they want Sierra to be able to walk, talk and see.

“Now we don’t know exactly which of those goals she’ll reach,” Rosetta said. “Our goal is, as parents, to push her to achieve her greatest potential, whatever that is. We’ll love her no matter what.”
The Fedelems said they spent more than$23,000 on treatments in China, but they raised $45,000. The rest of the funds went to a hyperbaric chamber, and other treatments Sierra will receive in Florida in two weeks.

To learn more about Sierra and how you can donate to help the family with medical expenses visit SightForSierra.com.
Dr. Prockup said the institute will be working on four clinical trials. By the end of the year he expects they’ll begin one with adult stem cell research for treatment on knee cartilage repair. The institute also plans to conduct stem cell research on diabetes, heart disease and strokes.

from News 8 Austin