“Latest Stem Cells News”

Stroke-damaged brains could be repaired within 5-10 years using adult stem cells from teeth, according to one of Australia’s leading stroke physicians who is pioneering new research in this field.

Associate Professor Simon Koblar from the University of Adelaide and The Queen Elizabeth Hospital is leading a research project that shows dental pulp stem cells extracted from teeth may prove far more beneficial for brain repair than other types of stem cells.

His research involving adult stem cells is the first of its kind in Australia and will be explained at a free public lecture at the University of Adelaide tomorrow night as part of the University’s highly successful Research Tuesdays monthly seminar series.

Stroke is the leading cause of disability in Australia, with 60,000 people suffering a stroke every year and approximately 30% of them losing their lives.

Assoc. Prof. Koblar says dental pulp stem cells have a natural ability to produce and repair neurones (nerve cells). Because they are in teeth, they can also be easily extracted and don’t pose rejection issues for patients.

In 2007 Assoc. Prof. Koblar was awarded $100,000 by the Catholic Archdiocese of Sydney for a collaborative pilot study on adult stem cells with Associate Professor Stan Gronthos from SA Pathology. Stroke SA also provided additional financial support for this project in 2009.

The two scientists are senior members of the University of Adelaide’s Centre for Stem Cell Research at the Robinson Institute.

“We have some very promising data from trials involving stroke-affected rats, who have shown an improvement in mobility when transplanted with dental pulp stem cells,” he says.

Assoc. Prof. Koblar says more research needs to be done to prove the benefit in animal models before it can be trialled in humans.

The Robinson Institute is currently working with University of Adelaide graduate and stroke victim Peter Couche to set up a Stem Cell for Stroke Foundation in his name.

“Like all research, what we can achieve will depend on how much money can be raised,” Assoc. Prof. Koblar says.

“Stem cell research has great potential to affect stroke patients and benefit the Australian community as a whole, because its impact in this country is enormous. Even if all we can do is to get someone’s hand function to improve, that would be a magnificent advance.”

An inaugural $75,000 collaborative research grant from the Centre for Stem Cell Research has been awarded to Associate Professors Koblar and Gronthos to continue their research into adult stem cell therapy for stroke patients.

from http://www.adelaide.edu.au/news/news37182.html

Sierra Rose Hill, a young girl from Australia with cerebral palsy who was already helped by Adult Stem Cells is off again to Germany for a 2nd stem cell treatment.  Sierra went to Germany in December, 2008 for the therapy with her own stem cells and it paid big dividends.  We first covered Sierra here in this stem cell post in March

Adult Stem Cells Successful First Time- Now Going for Two!

As a result of the first stem cell treatment, Sierra got “looser” in her limbs, more flexibility and a better ability to control her tongue. Sierra responded so well to her own Adult Stem Cells that her parents have now raised enough money to return to Germany for more stem cell therapy.

Stem Cell Research Documentary

Sierra and her parents are leaving for Germany on June 25th for the treatment. However, this time, they will have company. Pia Niebel is producing a documentary called ‘Little Mountains’ about Sierra and in Pia’s words:

‘Little Mountains’ is an intimate portrayal of an Australian family’s struggle with cerebral palsy and the risks and choices associated with emerging stem cell technologies. It is a character driven documentary that enquires about the current status of adult stem cell treatment and why it is not available in Australia.

Adult Stem Cells Available to Help In Australia? No

I often moan on how adult stem cells are not available in the United States.  However, of course, there are people everywhere who have diseases and conditions that adult stem cells could help.  There is no reason why Australia shouldn’t be making a person’s own stem cells available for treatment as well.

And as Sierra’s father said once  “If that (stem cell treatment) was available in Australia, at an affordable price, if it was at a hospital from a professional service, that could make such a huge difference to people with cerebral palsy and various other conditions,” he said. “I know they want to do their clinical trials. But they are providing this service already around the world. I would like to see it here.”

Pia is looking for funding to help her produce this Adult Stem Cell research documentary which would be a nice step in the right direction in getting Adult Stem Cell treatment approved in Australia.  If you would like to help Pia get the word out, you can contact her here:
Pia Niebel
LIGHT PUZZLE MEDIA
Creative Producer
mobile +61 (0)4 388 77 183
Email: happy@pia.net.au

Here is a preview of Pia’s stem cell research documentary featuring the lovely Sierra and her parents:

A young 16 year old boy with Type 2 Spinal Muscular Atrophy has returned home with noticeable improvements after receiving Adult stem cell research in China. Kyle Knopes, from Janesville, Wisconsin says his quality of life has improved tremendously after returning from China where he received adult stem cells taken from cord blood.

What is Spinal Muscular Atrophy?

Spinal Muscular Atrophy is a hereditary disease in which the person is missing a gene which is responsible for the production of the protein for motor neurons. Without this protein, the motor neuron in the spinal cord wither and die.

Before the Stem Cell Treatment in China

• Couldn’t open his fist
• Couldn’t roll over on his side by himself
• All muscles were very weak, could only hold empty cups

After the Stem Cell Therapy Using Adult Stem Cells

• Can open his fist and stretch his fingers by himself
• Can roll from his back onto his side all by himself
• Can now carry some weight, such as a bottle of apple juice rather than just empty cups
• Reports improved strength in all his muscles
• Daily tasks such as eating and writing are easier

Adult Stem Cells “Definitely” and “Absolutely” Worth It

When asked if the trip half way around the world from Wisconsin to China was worth it, Kyle replied “Definitely” and his mother chimed in with “Absolutely.”

From the stem cell article:

Kyle and Penny said they’re happy to have gone through all the fundraising and planning for the treatment that cost more than $30,000, plus expenses.

They’d even consider a second trip in a few years for more injections.

They met families from across the United States, Australia, United Arab Emirates, England and elsewhere during their stay.

“It was like one big family,” Kyle said.

Another Spinal Muscular Atrophy Patient Helped By Stem Cell Research

Coincidentally, or probably not so coincidentally, Kyle followed in the footsteps of another Janesville resident with Spinal Muscular Atrophy, Brandon Meinke.

This was a great story because a reporter from the local TV station followed Brandon before and after the stem cell treatment, documenting the improvements.

Brandon received stem cell treatment for his SMA and was able to walk again after the adult stem cells. You can see more on his stem cell therapy here.

original post by Don Margolis

Stem Cell Research using the patient’s own Adult Stem Cells has brought us another great discovery- Stem Cell Contact Lens. In Australia, a group of doctors in a research study treated 3 patients who had some form of cornea problems and they all were able to see after the stem cell treatment in which their own stem cells healed damage to their cornea

The Process of Stem Cells for the Cornea

1. The doctors removed Adult Stem Cells from the patient’s good eye
2. The stem cells were grown on a contact lens for 10 days
3. The contact lens was placed on the damaged eye for 3 weeks
4. The stem cells “blend” into the eye and repair the damage in the cornea

From the stem cell article:

The researchers, led by Dr Nick di Girolamo, said each person’s sight improved significantly within weeks of the procedure, and that it was a simple inexpensive technique which required a minimal hospital stay

Stem Cell Research Abstract

Also, here is the  stem cell research abstract for the cornea study.  Here are some of the actual results:

Results. A stable transparent corneal epithelium was restored in each patient. There was no recurrence of conjunctivalization or corneal vascularization, and a significant improvement in symptom score occurred in all patients. Best-corrected visual acuity was increased in all eyes after the procedure.

This technique is simple, non invasive, and uses the patient’s own stem cells– so the patient has nothing to lose and everything to gain by trying something like this.  What can be easier than popping in a contact lens?

Covering Old Stem Cell Ground?

However, it seems like they have doing something similar in India for a number of years. Notice in the story, that the doctors removed stem cells from the good eye of the patient. What happens if the patient has two bad eyes? Well there are  doctors in India are getting the stem cells from under the lip of the patient. This stem cell story didn’t get any run when it came out in October of 2008- but it probably should have. Read more about what this group of stem cell doctors in India have for stem cells for the cornea here

Scientists in Melbourne for the first time have created a human stem cell reserve in Australia using a technique that avoids destroying embryos, which was developed in Japan and the United States.

The team from the Monash medical research institute produced an induced pluripotent stem cell line (IpS) that acts like embryonic stem cells, but are derived from adult skin cells. The method used to reprogram adult stem cells developed last year in Japan and the United States allows for the production of IpSs, which are used to study degenerative diseases like Parkinson’s without having to deal with ethical objections.

Adult Stem Cells Improve Young Boy with Cerebral Palsy

Corey de Gregorio, a 3 year old boy from Gordonvale, Australia has improved tremendously after going to a Stem Cell research company which implanted Adult Stem Cells from cord blood into him.

Corey’s parents, Mark and Roseanne had doubts before going to China for the stem cell treatment, but they  wanted Corey to have every chance to live a better life and therefore, they made the journey to China for the stem cell therapy which used only Adult Stem Cells.

The miracle treatment consisted of six “therapies” of cord blood stem cells.

Before the Adult Stem Cells for Cerebral Palsy

• Had very little use of his left arm/hand
• Little movement in his torso

After the Stem Cell Treatment

• Can now use his left hand, can use it to drink a cup by himself
• Increased flexibility in torso