Tag Archive for 'Amyotrophic lateral sclerosis'

Wide-ranging applications for pluripotent stem cells

| Share

While applications of induced pluripotent stem cells in stem cell therapy may be limited to a few diseases, its applications in drug discovery are wide-ranging, and many more diseases can be targeted, Shinya Yamanaka, Director, Centre for iPS Cell Research and Application, Japan, has said.

The Japanese scientist, whose breakthrough was the creation of embryonic-like stem cells from adult skin cells, believes that the best chance for stem cell therapy lies in offering hope to those suffering from a few conditions, among them, macular disease, Type 1 Diabetes, and spinal cord injuries.

On the other hand, there were multiple possibilities with drug discovery for a range of diseases, and Prof. Yamanaka was hopeful that more scientists would continue to use iPS for studying this potential.

He currently serves as the Director of the Center for iPS Cell Research and Application and as Professor at the Institute for Frontier Medical Sciences at Kyoto University. He is also a Senior Investigator at the University of California, San Francisco (UCSF) – affiliated J. David Gladstone Institutes.

An invited speaker of the CellPress-TNQ India Distinguished Lectureship Series, co-sponsored by Cell Press and TNQ Books and Journals, Prof. Yamanaka spoke to a Chennai audience on Tuesday evening about those “immortal” cells, that he originally thought would take “forever” to create, but actually took only six years.

“My fixed vision for my research team was to re-programme adult cells to function like embryonic-like stem cells. I knew it could be done, but just didn’t know how to do it,” Prof. Yamanaka said.

Embryonic stem cells are important because they are pluripotent, or possess the ability to differentiate into any other type of cell, and are capable of rapid proliferation. However, despite the immense possibilities of that, embryonic cells are a mixed blessing: there are issues with post-transplant rejection (since they cannot be used from a patient’s own cells), and many countries of the world do not allow the use of human embryos.

Dr. Yamanaka’s solution would scale these challenges if only he and his team could find a way to endow non-embryonic cells with those two key characteristics of embryonic stem cells.

Maybe you can find something interesting in the following sponsored links:

Incoming search terms:

Published News Upcoming News Submit a New Story Groups abc television los angeles, katy piper stem cells ips, shinya Yamanaka cell press tnq.

Video: Neural Stem Cells and CNS Disorder

| Share

What is a neural stem cell? How can they help treat neurological disorders such as Alzheimer’s disease, Parkinson’s disease, spinal cord injury, stroke, ALS (Lou Gehrig‘s Disease)? Evan Snyder of the Burnham Institute helps define neural stem cells (NSC), explaining that they are relatively inaccessible in the adult patient, but that they seem to benefit from some immunotolerance.

It follows that we may be able to use readily available lines of embryonic stem cells for therapy in neurodegenerative disease. Evan reviews current clinical applications for neural stem cells (including as a vehicle for small molecule delivery), and gives his future outlook for neural stem cells. Evan forsees NSCs being used in anti-inflammatory and neuroprotective functions, to deliver tumor killing genes, and to build iPS drug discovery models.

Reblog this post [with Zemanta]

Incoming search terms:

Published News Upcoming News Submit a New Story Groups university of michigan, applications of stem cell technology for neurological disorders ppt, Published News Upcoming News Submit a New Story Groups auto show 2009, new compounds cns disorders ppt, Published News Upcoming News Submit a New Story Groups 2009 february job loss estimates, Published News Upcoming News Submit a New Story Groups show me movie times, als genetics ppt, stem cell biology in central nervous system ppt, ted harada als karl johe, testimonials from lou gehrigs patients about protandim, neural transplantation for the treatment of parkinson\s disease ppt, nervous system disorder ppt, als stem cells harada johe, can stem cells cure alzheimers disease, discoveries innervous system diseases presentation, dr nicholas boulis stem cell treatment cerebral palsy, ips cells cure altimers, latest stem cell discoveries, latest stem cell news neural, modeling ips cells diseases drug discovery ppt, university of michigan stem cell for als.

Brain stem cell transplant may pave way for Parkinson’s

| Share
200

Neuron transplants have repaired brain circuitry and substantially normalized function in mice with a brain disorder, an advance indicating that key areas of the mammalian brain are more reparable than was widely believed.

Collaborators from Harvard University, Massachusetts General Hospital (MGH), Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS) transplanted normally functioning embryonic neurons at a carefully selected stage of their development into the hypothalamus of mice unable to respond to leptin, a hormone that regulates metabolism and controls body weight. These mutant mice usually become morbidly obese, but the neuron transplants repaired defective brain circuits, enabling them to respond to leptin and thus experience substantially less weight gain.

Repair at the cellular-level of the hypothalamus — a critical and complex region of the brain that regulates phenomena such as hunger, metabolism, body temperature, and basic behaviors such as sex and aggression — indicates the possibility of new therapeutic approaches to even higher-level conditions such as spinal cord injury, autism, epilepsy, ALS  (Lou Gehrig’s disease), Parkinson’s disease, and Huntington’s disease.

In 2005, Harvard Medical School Dean Jeffrey Flier, then the George C. Reisman professor of medicine at BIDMC, published a landmark study showing that an experimental drug spurred the addition of new neurons in the hypothalamus and offered a potential treatment for obesity. File photo by Stephanie Mitchell/Harvard Staff Photographer

“There are only two areas of the brain that are known to normally undergo ongoing large-scale neuronal replacement during adulthood on a cellular level — so-called ‘neurogenesis,’ or the birth of new neurons — the olfactory bulb and the subregion of the hippocampus called the dentate gyrus, with emerging evidence of lower level ongoing neurogenesis in the hypothalamus,” said Jeffrey Macklis, Harvard University professor of stem cell and regenerative biology and HMS professor of neurology at MGH, and one of three corresponding authors on the paper. “The neurons that are added during adulthood in both regions are generally smallish and are thought to act a bit like volume controls over specific signaling.  Here we’ve rewired a high-level system of brain circuitry that does not naturally experience neurogenesis, and this restored substantially normal function.”

Incoming search terms:

harvard medical school logo, Jeffrey Scott Flier Harvard Medical School, Published News Upcoming News Submit a New Story Groups drug test hair pass proven, Published News Upcoming News Submit a New Story Groups online self diagnosis for medical conditions, parkinsons latest news dec 201, how does the new discovery of repairing brain cells cure parkinson\s, parkinsons 2012 cure medical, very recent news about the thr trial of dichloroacetate with primary pulmonary hypertension people, parkinsons 2012, parkinsons latest developments, parkinson stam cell 2012, news on parkinsonslatest d, parkinson\s 2012, parkinsons cure found in china, parkinson\s latest advances 2012, Published News Upcoming News Submit a New Story Groups fox television careers, what do live cell therapy hypothalamus cells do for the brain, stem cells grows hairs in brain china, stem cell transplants for parkinson\s patients 2012, stem cell transplant repair brain stem, stem cell transplant may pave a way to parkinson disease, self brain cell transplant cure parkinson, Published News Upcoming News Submit a New Story Groups safety act, Published News Upcoming News Submit a New Story Groups kinds of medicine, mgh transplant enter, medical sculpture transpllant massachusettes, how fetus stem cell cure parkinsons 2012, 2012 major breakthroughs for Parkinsons at Harvard Medical school, how are brain stem cell transplant performed china, harvard university H logo, harvard medical school mass general, fox news harvard lung stem cells, fetal stem cell transplant in parkinsons success 2012, brain stem cells harvard, brain stem cell transplant jeffery macklis at harvard university, hypothalamus & cell therapy, hypothalamus stem cells and alzheimers, medical discoveries with hypothalamus, medical breakthroughs 2012 neuro, medical breakthrough involving the hypothalamus, medical breakthrough curing alzheimer\s 2012, medical advances in parkinson\s january 2012, master zhou als treatment, latest parkinsons news.

Emory Conducting Landmark Study to Treat ALS

| Share

Emory University researchers are participating in a groundbreaking clinical trial to treat patients with amyotrophic lateral sclerosis (ALS) using human neural stem cells.

The Phase 1 trial, will assess the safety of stem cells, and the surgical procedures and devices required, for multiple injections of the cells directly into the spinal cord.

“This is the first U.S. clinical trial of stem cell injections into the spinal cord for the treatment of ALS,” says principal researcher Jonathan Glass, professor of neurology in the School of Medicin, and director of the Emory ALS Center. “Our main goal in this early phase is to determine whether it is safe to inject stem cells into the spinal cord and whether the cells themselves are safe.”

Three patients with ALS have received injections since the trial began in January. Up to twelve individuals will be enrolled at in this phase of the trial.

Nicholas Boulis, assistant professor of neurosurgery I the School of Medicine and a pioneer in developing surgical methods for delivery of therapeutics to the spinal cord, is performing the surgical procedures.

Incoming search terms:

spinal injury repair 2012, cure for als 2012, als cure news, als treatment 2012, sma cure 2012, recent blog on als treatment at emory university, Published News Upcoming News Submit a New Story Groups employee performance reviews, ALS stem cells december 2011, spinal muscular atrophy stem cell treatment december 2011, als cure found 2012, cure als 2012, protandim cure als, protandim and als, optic nerve clinical trials emory hospital, pumps in spinal cord to treat ALS, news of treatment in switzerland, sciatic nerve stemtech, sma disease news 2012, therapy for sma atrophy 2012, spinal cord tumor at emory, spinal injury treatment repair dec 2011, spinal injury treatments switzerland news 2011, spinal muscle atrophy research in switzerland news 2011 2011, spinal muscular atrophy stem cell treatment germany, spinal muscular atrophy stem cells january 2012, New treatment for muscular atrophy disease 2012, new reserch for spinal muscl atrophy treatment in usa in 2012, can atrophied muscle be rebuilt in als, als treatments 2012, als treatment of the disease found, ALS stem cell 2012, als new stem cell treatment 2012, als new 2012, als emory stem cells study, als cure found, cure sma news 2012, emory university hospital fetal stem cells trial for als, new methods for als treatment in usa in 2012, new als treatments 2012, medicine for als 2012, jan 31 als research 2012, interesting 2011-2012 study of cells, how to get in spinal stem cell trials 2012, first als case treated with stem cell reversed.

Neuralstem gets FDA OK for Stem cell trial for ALS treatment

| Share

Neuralstem Inc. has received the green light to begin the first human stem cell trial to treat Amyotrophic Lateral Sclerosis (ALS), often referred to as Lou Gehrig’s disease. The company’s stock soared on the news.

Neuralstem has only received approval for the first stage of the trial that would consist of 12 patients who will receive stem cell injections in the lumbar area of the spinal cord.

Neuralstem said the trial will be under the direction of principal investigator Dr. Eva L. Feldman, Director of the University of Michigan Health System ALS Clinic and the Program for Neurology Research & Discovery. Feldman called the trial a major step forward in the treatment of ALS. “In work with animals, these spinal cord stem cells both protected at-risk motor neurons and made connections to the neurons controlling muscles. We don’t want to raise expectations unduly, but we believe these stem cells could produce similar results in patients with ALS,” Dr. Feldman said.

from

http://washington.bizjournals.com/washington/stories/2009/09/21/daily7.html

http://www.reuters.com/article/americasRegulatoryNews/idUSBNG36053620090921

Reblog this post [with Zemanta]

Incoming search terms:

baldness news 2012, als news 2012, stem cell for hair loss 2012, als new treatment 2012, hair loss 2012, baldness cure december 2011, hairloss news 2012, will there be a cure for baldness 2012, baldness cured in 2012, balding cures 2012, how close is a cure for baldness, stem to cure als 2012 treatment, cure for als, research on baldness 2012, news baldness 2012, new products to cure baldness 2012, hair growth news 2012, new baldness cure usc, are we close to a cure for baldness, any hope on hair loss 2012, 2012 hairloss products, latest baldness news 2012, 2012 hair research update, 2012 baldness research, wiki baldness cure 2012, promising hair loss treatments 2011, how close to a cure for als, how close to the cure for als, when will they cure baldness?, Is neural stem cell therapy promising for ALS treatment?, new hair growth treatment 2012, new cure baldness 2012, Lab-grown cells \treat baldness\ 2012 update, latest cure for baldness research, latest baldness news 29 december 2011, when will they cure als, promising research on als 2012, when will there be a hair loss cure, stem cell treatment for hair growth 2012, stem cells hair loss 2012, stem cell therapy revolution 2011, stem cell therapy for hair loss 2012, revolutionary baldness cure 2012, stem cell research for hair loss 2012.

FDA Approves Continuation of ALS Stem Cell Trial

| Share

Emory University researchers have received approval from the Food and Drug Administration (FDA) to advance to the next phase of a landmark trial to treat patients with Amyotrophic Lateral Sclerosis (ALS) using human neural stem cells.

The Phase I trial, currently underway exclusively at Emory University, is designed to assess the safety of implanting neural stem cells into the spinal cord in up to 18 people with ALS and began in January 2010. The first 12 patients received neural stem cell transplants in the lumbar, or lower, region of the spinal cord. After reviewing safety data from these patients, the FDA has granted approval for the trial to advance to the final two groups of patients (three in each group), all of who will be transplanted in the cervical, or upper, region of the spinal cord.

“This represents a major accomplishment for the trial, meaning that we have achieved our stated goal of proving safety in the first 12 patients who received lumbar spinal injections,” says Jonathan Glass, MD, Professor of Neurology, Emory School of Medicine and director of the Emory ALS Center.

“Our next objective is to demonstrate that we can deliver the cells safely to the cervical spinal cord, which is particularly important because therapy in this region may help patients better maintain their ability to breathe.”

Incoming search terms:

harada neuralstem, neural stem cells cure for diabetes 25th october 2011, ted harada als november 2011, stem cell umbilical cord fda approval, neuralstem baldness als treatment, ted harada als trial, lateral sclerosis stem cells 2011, lateral sclerosis neuralstem 2011, I still think there is a cure or treatment for ALS if theFDA a would release it Oct 2011, 2011 gene therapy for als, gene therapy for als in 2011, 2011 is stem cell implatation safe, als and phase 1 stem cell trials, als patients who have had fetal stem cell implants ---, als stem cell 2011, als stem cell trial in italy, cnn sclerosys lateral amyotrofic harada neuralstem, cure for als november 2011, gene therapy als november 2011, Ted\s story stem cell ALS Emory.

Share to Facebook Share to Twitter Stumble It Email This More...
Related pages on the web
  • Cord Blood Donation As I have mentioned before, there is a ton to think about before having a baby. These days with so much information out there, it's hard NOT to over think things. Especially when you are me. You even find yourself...
  • 5 More Healthy and Permanent Weight Loss Tips Make your number one goal health rather than weight loss. If you are setting your goal as a healthy lifestyle, then you are much more likely to succeed not only in improving your health but also in attaining a permanent...
  • Too Much Technology? These days, people are constantly "connected" to their hand-held devices, whether it is their cellular phones, portable video games like Nintendo DS, e-readers such as Amazon Kindle, or they are just using apps on an iPhone. A survey found that young...
  • Patients Speak Out About What It Is Really Like To Be Ill Today .!. What's it like to be a patient facing serious illness in today's medical environment? The New York Times has a very detailed series of interviews with real patients facing such illnesses as stroke, Parkinson's, Prostate Cancer, Bipolar Disorder, Spinal...
  • Collecting Wine Bottle Corks Most people are familiar with collecting wine, and even collecting wine bottles, but one of the types of collections that some people are unaware of is collecting wine bottle corks. Wine bottle corks are often just as unique as the...
Blog Traffic Exchange Related articles on this site