Harvard Stem Cell Institute (HSCI) scientists collaborating with researchers at the University of Pennsylvania have developed a “genome-editing” approach for permanently reducing cholesterol levels in mice through a single injection, a development that could reduce the risk of heart attacks in humans by 40 to 90 percent.
“For the first iteration of an experiment, this was pretty remarkable,” said Kiran Musunuru of HSCI, an assistant professor in Harvard’s Department of Stem Cell and Regenerative Biology (SCRB), and a cardiologist at Harvard-affiliated Brigham and Women’s Hospital. Musunuru stressed, however, that it could take a decade of concerted effort to get this
Image by Gabriela Camerotti via Flickr
Those suffering from a damaged heart can be treated with their own heart cells. According to a recent research, heart stem cells from children with congenital heart disease can rebuild the damaged heart in the laboratory. The findings apparently have great significance in the health zone.
While conducting the research, cells were achieved from patients ranging in age from a few days after birth to 13 years. These patients were previously subjected to routine congenital cardiac surgery. The number of heart stem cells appears greatest in neonates, that reduce with progression in age. Majority of
Image via Wikipedia
A new research has suggested that cardiac stem cells – even in elderly and sick patients – could generate new heart muscle and vessel tissue and be used to treat heart failure.
Scientists surgically removed tissue from the muscular wall of the heart’s chambers in 21 patients.
They then isolated and multiplied the cardiac stem cells (CSCs) found there.
Most of the patients had ischemic cardiomyopathy (enlarged and weakened muscle due to coronary artery disease). Eleven also had diabetes. The average age of patients was about 65.
“Regardless of the gender or age of the patient, or of diabetes, we were
An emergency helicopter trip in May that brought a stroke patient from Forrest General Hospital in Hattiesburg landed the Clarke County resident the first spot in a clinical trial at the University of Mississippi Medical Center for stem-cell therapy.
The new therapy could prevent further brain injury following the initial stroke, preserve vital motor and cognitive abilities and shorten recovery times.
The stem-cell treatment also could add a full day to a narrow four-and-a-half-hour window when current drug treatments work best.
The UMMC Comprehensive Stroke Center is one of 10 U.S. sites enrolling a total of 120 patients into the study. The
Damaged and aged heart tissue of older heart failure External link patients was rejuvenated by stem cells modified by scientists, according to research presented at the American Heart Association’s Basic Cardiovascular Sciences 2012 Scientific Sessions.
The study is simultaneously published in the Journal of the American College of Cardiology.
The research could one day lead to new treatments for heart failure patients, researchers said.
“Since patients with heart failure are normally elderly, their cardiac stem cells aren’t very healthy,” said Sadia Mohsin, Ph.D., one of the study authors and a post-doctoral research scholar at San Diego State University’s Heart Institute