Damaged and aged heart tissue of older heart failure External link patients was rejuvenated by stem cells modified by scientists, according to research presented at the American Heart Association’s Basic Cardiovascular Sciences 2012 Scientific Sessions.
The study is simultaneously published in the Journal of the American College of Cardiology.
The research could one day lead to new treatments for heart failure patients, researchers said.
“Since patients with heart failure are normally elderly, their cardiac stem cells aren’t very healthy,” said Sadia Mohsin, Ph.D., one of the study authors and a post-doctoral research scholar at San Diego State University’s Heart Institute
Researchers have reversed aging in old mice by injecting them with a longevity gene and rejuvenating their stem cells‘ regenerative potential.
The study by University of California-Berkeley biologists represents a major advance in understanding the molecular mechanisms behind aging, paving the way for the development of targeted treatments for age-related degenerative diseases.
The found that SIRT3, one among a class of proteins known as sirtuins, plays an important role in helping aged blood stem cells cope with stress, the journal Cell reports.
When they infused the blood stem cells of old mice with SIRT3, the treatment boosted the formation of new blood
Stem cells are not invincible and therefore not likely to be the magic wand in the world of medicine, but they may be a great clue in finding what will be, a research professor explained on Thursday.
As part of a stem cell seminar series, Barbara Driscoll, Ph. D presented a lecture in the U Building titled “The Impact of Aging on Stem Cells.” The presentation covered basic information about stem cells, the aging process of mammals and how the two are so crucial to the next great discovery in medicine.
Driscoll is an assistant professor of Developmental Biology at USC