Stem cells hold promise for male sterility

(Stem Cells News image)

A Montana State University researcher and her co-researchers are receiving international attention for showing that skin cells from infertile men can be used to create the precursors of sperm – research that holds promise for treating male infertility (…)

The team took skin cells from men who suffer from a genetic disorder, known as azoospermia, which prevents them from producing sperm. Those skin cells were then turned into stem cells, specifically, induced pluripotent stem cells, or iPSC. Like other stem cells, iPSC have the ability to become any other type of cell.

The team then implanted the stem cells into the testes of mice where they produced the precursors to sperm. It was the first time such work has ever been done.

The research was carried out at Stanford University, but the paper was written at Montana State University by senior author Renee Reijo Pera, MSU’s new vice president for research. Reijo Pera came to MSU in January from Stanford where she had been director of Stanford University’s Center for Human Pluripotent Stem Cell Research and Education and the Center for Reproductive and Stem Cell Biology. She is regarded as one of the world authorities on embryonic stem cells.

The success of the stem cells in forming the precursors to sperm in the mice offer scientists a new way to study the causes of, and possible treatments for, male infertility. The findings hold promise that one day infertile men could have their own cells implanted in their testes as a treatment for infertility (…)

Read more:montana.edu/news/12625/reijo-pera-and-team-stem-cell-research-holds-promise-for-male-infertility

One thought on “Stem cells hold promise for male sterility”

  1. A new study has found that stem cells made from the skin of adult, infertile men yield primordial germ cells — cells that normally become sperm — when transplanted into the reproductive system of mice.

    The infertile men in the study each had a type of genetic mutation that prevented them from making mature sperm — a condition called azoospermia.

    The research at the Stanford University School of Medicine and Montana State University suggests that the men with azoospermia may have had germ cells at some point in their early lives, but lost them as they matured to adulthood.

    Although the researchers were able to create primordial germ cells from the infertile men, their stem cells made far fewer of these sperm progenitors than did stem cells from men without the mutations.

    The research provides a useful, much-needed model to study the earliest steps of human reproduction.

    “We saw better germ-cell differentiation in this transplantation model than we’ve ever seen,” Renee Reijo Pera, PhD, former director of Stanford’s Center for Human Embryonic Stem Cell Research and Education said.

    “We were amazed by the efficiency. Our dream is to use this model to make a genetic map of human germ-cell differentiation, including some of the very earliest stages,” Pera said.

    The research is set to be published in Cell Reports.

    http://timesofindia.indiatimes.com/life-style/health-fitness/health/Fresh-hope-for-infertile-men/articleshow/34536948.cms

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