Featuring beautiful hand-drawn animations and interviews with leading stem cell scientists, STEM CELL REVOLUTIONS charts the history and scientific evolution of stem cell research – from the earliest experiments that first revealed stem cells in the body, to leading current scientific and clinical developments.
Supported by the Wellcome Trust and made by the same team as behind our four short films, Stem Cell Stories, this documentary is a genuinely creative collaboration between scientists and filmmakers.
STEM CELL REVOLUTIONS features eminent international scientists in stem cell research including Nobel Laureate Sir Martin Evans and Sir Ian Wilmut, creator of Dolly the sheep, and acclaimed novelist Margaret Atwood.
Hug-doctor-and-patient.jpgIt is a historic moment for stem cell biology – not only have stem cells themselves vitally changed our understanding of the human body, but the recent breakthrough by one of our main characters, iPS pioneer Shinya Yamanaka, has been hailed as “the biggest breakthrough since stem cells changed our understanding of how the body works.”
Our documentary features the world’s leading stem cell scientists.
Professor Austin Smith
has expertise in the field of mouse developmental biology and has pioneered key advances in the field of embryonic stem cell research. In January 2010 he was awarded the prestigious Louis-Jeantet Prize for Medicine. You can view a short video describing Austin’s research interests and motivations on the Louis-Jeantet Foundation‘s website.
Director, Wellcome Trust Centre for Stem Cell Research, University of Cambridge.
Professor Howard Green
is a founding father of regenerative medicine. He developed the first therapeutic use of cultured cells: the use of keratinocytes for the regeneration of epidermis on severely burned patients. The first large-scale, life-saving use of this procedure was demonstrated with cells grown in his laboratory to generate skin grafts.
Professor Shinya Yamanaka
and his colleagues successfully reprogrammed adult skin cells into the equivalent of embryonic stem cells – induced Pluripotent Stem Cells (iPS), first in mice, then with human cells. This breakthrough dramatically changed the landscape of stem cell science.
Director, Center for iPS Cell Research and Application, Kyoto University, Japan
Professor Sir Martin Evans
is the winner of the Nobel Prize for Medicine 2007. He was the first to isolate embryonic stem cells from early mice embryos and to cultivate them in a laboratory.
He then genetically modified these stem cells and implanted them into adult female mice to create genetically modified offspring. Genetically modified mice are now considered vital for medical research.
Professor Pete Coffey
aims to develop a stem cell therapy for the majority of all types of age-related macular degeneration. Human clinical trials are expected to start at the end of 2011.
Director, London Project to Cure Blindness
Professor Geeta Vemuganti
developed in-vitro culture and expansion of human limbal epithelial cells. Tissue is first harvested from the good eye of a chemically burnt patient with limbal damages.
Director, Ophthalmic Pathology Service, LV Prasad Eye Institute, Hyderabad, India
Surgeon Dr Virender Sangwan
transplants the cultured limbal epithelial cells to the patient, creating a bespoke cell replacement therapy.
Associate Director, Ophthalmic Pathology Service, LV Prasad Eye Institute
Professor Connie Eaves
is internationally recognized for her pioneering research in basic blood stem cell biology, which led to a breakthrough in treatment for leukemia.
Director and co-founder, Terry Fox Laboratory, Vancouver, Canada.
Professor Oliver Brüstle
and his research group focus on the use of embryonic stem (ES) cells for neural repair. Oliver Brüstle and his team have been able to demonstrate that transplanted ES cell-derived neurons and glia integrate into the host brain circuitry.
Director, Institute of Reconstructive Neurobiology, Bonn University, Germany
read more: http://www.stemcellrevolutions.com