Stem cell research can find treatment for kidney and renal diseases

(Stem Cells News image)

One in 10 adults in the U.S. — more than 20 million people — are suffering from some degree of chronic kidney disease. Kidney transplants offer a hope for cure, but thousands of patients die each year due to a shortage of donor organs. Even patients who are lucky enough to receive transplants run the risk of their immune systems rejecting the donor kidneys, and they have to take immunosuppressive drugs with serious side effects for the rest of their lives.

Vito Campese, professor and chair of the Keck School of Medicine of USC’s nephrology division, underscores the need to find novel stem cell-based therapies for these patients.

“Despite enormous progress made in the last 50 years, as of today, we do not know the causes of many kidney diseases and how to best treat them,” said Campese, who also chairs the Medical Scientific Advisory Board of the University Kidney Research Organization (UKRO), a Los Angeles-based nonprofit group that recently established the USC/UKRO Kidney Research Center at the Keck School (…)

The promise of such research is to usher in the era of regenerative medicine, which uses the power of stem cells to restore the function of damaged tissues or organs.

As the director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, McMahon is encouraging colleagues across USC to follow his lead in discovering new regenerative therapies for a broad array of diseases.

To this end, he recently recruited three stellar young faculty members: Justin Ichida, Rong Lu and Min Yu.

Ichida is leading the USC stem cell research center’s newly opened Choi Family Therapeutic Screening Facility, where scientists can test potential drugs on reprogrammed stem cells from patients. As a postdoctoral scholar at Harvard, Ichida laid the foundation for his current research by helping identify new ways to make induced pluripotent stem (iPS) cells.

“I just want to do something that really changes people’s lives,” he said.

Lu’s research is equally transformative: Her studies of what makes one blood stem cell outcompete another have ramifications for improving bone marrow transplants and preventing blood cancers. As a postdoctoral scholar at Stanford University, Lu came up with the idea of “barcoding” individual blood stem cells by labeling them with a genetic marker. This allows her to observe individual cells’ behavior, interactions, self-renewal or differentiation and contributions to forming blood.

“The most important reason I came to USC is the people here,” Lu said. “The stem cell department is growing, and everybody’s having new ideas and really being interactive and collaborative. You can feel the energy here.”

This dynamic, multidisciplinary research environment also attracted Yu, whose research focuses on finding new cures for breast cancer. Recruited in conjunction with the USC Norris Comprehensive Cancer Center, Yu filters out circulating breast cancer stem cells from billions of other blood cells to understand how the disease spreads and stop it in its tracks (…)

These and the next wave of recruitments already underway will benefit from a $2 million gift from the Eli and Edythe Broad Foundation. The gift establishes the Broad Fellows Program, provides seed funding to early stage research initiatives and supports the stem cell research center’s state-of-the-art facilities in imaging, therapeutic screening, flow cytometry, and stem cell isolation and culture.

McMahon is mentoring the next generation as the director of the new Department of Stem Cell Biology and Regenerative Medicine, which offers a Ph.D., Master of Science and undergraduate courses, the first of which was taught by McMahon for 19 students on the University Park Campus this spring. The center also hosts a unique internship opportunity for talented high school students.

To further harness the power of collaboration, McMahon leads the university-wide USC Stem Cell initiative, bringing together more than 100 faculty members from all disciplines.

As part of USC Stem Cell, Keck School Dean Carmen A. Puliafito provided $1.2 million in Regenerative Medicine Initiative awards to three disease teams to take early steps toward stem-cell based therapies for certain forms of deafness, bone defects and pediatric leukemia.

A fourth USC Stem Cell Kidney Disease Team is advancing the synergy between different laboratories across USC. Janos Peti-Peterdi is leading monthly meetings with USC kidney researchers McMahon, Campese, Laura Perin, Alicia McDonough and others.

The interdisciplinary effort extends beyond medical research. An economic impact analysis of Proposition 71, which created CIRM to fund stem cell research, is being planned with the USC Marshall School of Business. Students from the USC Roski School of Art and Design have conducted spring coursework in the center, finding inspiration from the beauty of science in action.

In the years to come, USC will continue to shape our future as stem cell biology moves from discoveries to cures (…)

read more:news.usc.edu/64927/stem-cell-research-may-unlock-cures-for-kidney-disease-and-more/

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