“Latest Stem Cells News”

A compound found in fish oil, which apparently kills leukaemia stem cells, may lead to the cure of the disease, a new study including Indian origin researcher has revealed.

The compound, delta-12-protaglandin J3, or D12-PGJ3 targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice, according to Sandeep Prabhu, associate professor of immunology and molecular toxicology in the Department of Veterinary and Medical Sciences.

He said that the compound is produced from EPA, Eicosapentaenoic Acid, an Omega-3 fatty acid found in fish and in fish oil.

“Research in the past on fatty acids has shown the health benefits of fatty acids on cardiovascular system and brain development, particularly in infants, but we have shown that some metabolites of Omega-3 have the ability to selectively kill the leukemia-causing stem cells in mice,” said Prabhu. “The important thing is that the mice were completely cured of leukemia with no relapse,” he noted.

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Howie Lindeman was facing the loss of his career and Neim Malo wasn’t supposed to see 2011. They were each treated for heart disease years ago using their own stem cells to repair their damaged heart tissue. Several years following treatment, both men continue to see improvement in their condition and quality of life.

Howie Lindeman, 60, had a heart attack at 39 years old that severely damaged his heart. He went through several procedures including having stents placed in his arteries and his physicians were considering open heart surgery for a quintuple bypass. He was in constant pain and struggled to walk just 25 feet, but when Zannos G. Grekos, MD, MAAC, FACC, chief medical officer of Regenocyte and a Florida-based pioneer in the field of adult stem cell therapy suggested he have the Regenocyte Adult Stem Cell procedure, he jumped at the opportunity. A normal ejection fraction (EF) is over 50 percent and Lindeman’s was down to a dangerous 22 percent before the adult stem cell procedure. Shortly after receiving treatment, his EF improved to a near-normal 47 percent, and is now at a stable 54 percent.

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THE SWIRL of controversy that greeted President Obama’s executive order lifting the ban on federal funding of stem cell research in March didn’t make a significant return when the final rules were released over the summer. That’s because the National Institutes of Health successfully navigated a minefield of ethical and moral questions. To protect those regulations from politics and changes by another administration, Rep. Diana DeGette (D-Colo.) soon will introduce the Stem Cell Research Enhancement Act of 2009. The legislation would codify Mr. Obama’s executive order permitting federal funding of such research within guidelines established by the NIH and would require that they be reviewed periodically (…)

Mr. Obama’s executive order overturned one issued by President George W. Bush in 2001 that allowed federal funding only for those stem cell lines already developed. Scientists ultimately found the number of approved lines too few and the utility of those lines limited.

For facilities with stem cell lines developed on or before July 7, the NIH will establish a committee of scientists, ethicists and advocates to examine on a case-by-case basis the procedures and paperwork to determine whether the lines were derived with voluntary informed consent from donors and in a manner consistent with the new rules. This panel would also make the same evaluation of stem cell lines originating outside the United States. There are an estimated 700 stem cell lines already in existence.

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Statement by Maurizio Bolognetti, Secretary of the Associazione Radicali Lucani (Radical Association of the Lucania Area)

As recently stated, Senators Perduca and Poretti have questioned individuals about the stem cell bank in Matera. After three years, it is necessary to finally shed light on the matter, which has not been clearly explained. The many mothers who have donated umbilical cords have the right to know the truth about how and why an opportunity to potentially treat individuals was lost. EU Parliament member Marco Cappalto expressed his desire for Minister Sacconi to provide clear responses.

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The text of the questioning follows:

Questioning of the Minister for Labour Policy Maurizio Sacconi by Senators Perduca and Poretti

Considering that

On December 31 1996, with regional law number 478, the regional council in Basilicata instituted an umbilical cord stem cell bank at the Matera Hospital.

In 2004, the umbilical cord stem cell bank was transferred to the Microcythemia Center where the bank was put under the direct responsibility of Doctor Carlo Gaudiano at the Transfusion Center at “Madonna delle Grazie” Hospital in Matera.

In the summer of 2006, some donors learned about the destruction (others believe the disappearance) of umbilical cord stem cells. The matter was debated upon for months by the national and local media and in particular by the ‘Quotidiano della Basilicata’ on April 7 2006. Weekly magazine in Matera, Il Resto, Sole 24 Ore, and Corriere della Sera newspapers also covered the story. The matter came to the attention of the Public Prosecutor’s office of Catanzaro.

We hereby ask:

If and in what way the stem cells were lost;

Who exactly and which professionals in general were trained in the removal, handling, and freezing of stem cells;

What and how much equipment was acquired and what was its purpose;

The total cost of the operation after revenue earned.

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The master regulator of muscle differentiation, MyoD, functions early in myogenesis to help stem cells proliferate in response to muscle injury, according to researchers at Case Western Reserve University.
The study appears online Jan. 4 in the Journal of Cell Biology.

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