Synthetic Stem Cells for Therapeutic Benefits

Researchers from North Carolina State University, the University of North Carolina at Chapel Hill and First Affiliated Hospital of Zhengzhou University have developed a synthetic version of a cardiac stem cell.

These synthetic stem cells offer therapeutic benefits comparable to those from natural stem cells and could reduce some of the risks associated with stem cell therapies. Additionally, these cells have better preservation stability and the technology is generalizable to other types of stem cells.

Stem cell therapies work by promoting endogenous repair; that is, they aid damaged tissue in repairing itself by secreting “paracrine factors,” including proteins and genetic materials.

While
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Recovering From Radiation and Chemotherapy

Researchers at the University of California, San Diego School of Medicine report that a protein called beta-catenin plays a critical, and previously unappreciated, role in promoting recovery of stricken hematopoietic stem cells after radiation exposure.

The findings, published in the May 1 issue of Genes and Development, provide a new understanding of how radiation impacts cellular and molecular processes, but perhaps more importantly, they suggest new possibilities for improving hematopoietic stem cell regeneration in the bone marrow following cancer radiation treatment.

Ionizing radiation exposure – accidental or deliberate – can be fatal due to widespread destruction of hematopoietic stem cells, the
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Stem cell regenerates heart muscle

Stem cell therapy can regenerate heart muscle in primates, according to a University of Washington study.

The scientists on this and related projects are seeking way to repair hearts weakened by myocardial infarctions.

This all-too-common type of heart attack blocks a major artery and deprives heart muscle of oxygen.

People who survive a severe episode often continue their lives in poor health because their hearts no longer work properly. The researchers hope eventually to restore such failing hearts to normal function.

Their approach uses heart cells created from human embryonic stem cells

The researchers tested the possibility of producing enough of these cardiac muscle
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Stem cells: bone marrow transplants (BMT)

Early September 2016, on a late evening I received a call from the E.R (Emergency Room) that a young 18 year old boy’s family was seeking an emergency opinion from a hematologist for their son.

He was found to have severe pancytopenia [severe reduction of all three cell lines –Hemoglobin (Hb), white blood cells (WBCs) and platelets] noted on a blood count (CBC) done for progressive fatigue over a month, and new onset rashes all over his body since a day.

His evaluation revealed a related rare disorder of the bone marrow, called severe aplastic anemia (SAA), that occurs due to
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STEM CELLS BATTLE FOR SPACE

The body is a battle zone. Cells constantly compete with one another for space and dominance. Though the manner in which some cells win this competition is well known to be the survival of the fittest, how stem cells duke it out for space and survival is not as clear. A study on fruit flies published in the October 2 issue of Science by Johns Hopkins researchers describes how stem cells win this battle by literally sticking around.

“Our work exemplifies how one signal coordinately maintains two types of stem cells in a single niche, or microenvironment,” says Erika Matunis,
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news from the world about stem cells