“Latest Stem Cells News”

Don’t look for this just yet at your neighborhood clinic, but Minnesota scientists are pushing stem cell therapies into new frontiers — into territory that is so open that doctors and regulators still are shaping practices and policies as they go along.

In one breakthrough, researchers at Mayo Clinic in Rochester obtained stem cells derived from the bone marrow of heart disease patients and guided the cells to help heal, repair and regenerate damaged heart tissue. This is “landmark work,” said an editorial accompanying their research report in Monday’s Journal of the American College of Cardiology.

And last week, University of Minnesota researchers reported in the New England Journal of Medicine that they had for the first time used stem cells from bone marrow to help children who suffer from a rare, fatal skin disease.

While these advances are significant, they also show why we have to be patient about waiting for stem cells to deliver their seemingly magical healing power for every day therapy. That has been especially true while ethical, religious and political concerns held up research on stem cells derived from early embryos.

But even with so-called adult stem cells (those not from early embryos), it takes years of painstaking work to isolate just the right cells and then concoct cultures that will not only nurture them in the laboratory but also coax them to perform new functions.

Cancer patients in remission at a Suffolk hospital can have their own cells transplanted back to them with the use of a new piece of equipment.

The stem-cell bath defrosts frozen cells taken from people recovering from blood cancers myeloma, leukaemia and lymphoma at Ipswich Hospital.

When transplanted back to the patient following treatment the cells can help their body create new bone marrow.

The bath cuts down on the need for patients to travel to other hospitals.

The stem cells are stored at -190C in liquid nitrogen and can be kept for several years at the national blood transfusion centre in Cambridge.

They are then brought up to body temperature in just two minutes using the bath, the hospital said.

Hermione Warner-Charlick, haematology clinical nurse specialist, said: “The new bath is important because it quickly defrosts the frozen cells to give them back to the patient safely.”

British scientists have created human red blood cells from spare embryonic stem cells, a major breakthrough they claim could soon pave the way for production of synthetic ‘O-negative‘ blood for medical transfusions.

The red blood cells have been produced from stem cells from spare IVF embryos as part of a three-billion-pound project to develop an alternative source of O-negative blood, the universal donor group which can be transfused into people without fear of rejection, ‘The Independent’ reported.

In their research, the scientists used more than a 100 spare embryos left over from treatment at fertility clinics to establish several embryonic stem cell “lines“. A line, RC-7, was transformed into blood stem cells before being converted into red cells containing oxygen-carrying haemoglobin.

Prof Marc Turner, the Director of the Scottish National Blood Transfusion Service in Edinburgh and leader of the project, said that synthetic blood made on an industrial scale would overcome the problem of blood shortages and risk of transmitting new infections between donors and recipients. “We’ve proved the principle that from these embryonic stem cell lines we can generate red blood cells.

“At the end of this three-year period we would envisage generating up to one unit (a pint) of red cells from embryonic stem cells at clinical grade which fulfil all the in vitro characteristics of red cells,” Prof Turner was quoted as saying.

The past few years brought high development in obtaining and culturing autologous adult stem cells. In this paper we review publications of experimental investigations and clinical trials of the muscle-derived cells and the application in the treatment of stress urinary incontinence among women. Mesenchymal stem cells (MSCs) can be obtained from bone marrow but it is associated with a painful biopsy procedure.

Collection of muscle-derived stem cells (MDSCs) is less harmful because the skeletal muscle biopsy is performed with a small caliber needle in local anesthesia. The stem-based therapy could be the next step in the treatment of urinary incontinence. There are still many elements of therapy such as effectiveness or long-term side effects which need to be researched.

Department of Gynecology and Oncology, Collegium Medium Jagiellonian University of Kraków
Dr Klaudia STANGEL-WÓJCIKIEWICZ

“The tracheal team at Great Ormond Street Hospital is delighted that Ciaran is going home after his tracheal transplant. He is a wonderful boy who has become a great friend to us all, and he and his infinitely patient family have charmed us all. Ciaran has become our local iPad expert, and we will miss his advice. His recovery has been complicated, as one might expect for a new procedure, and we have kept him under close surveillance, hence the length of time he has been here. It is wonderful to see him active, smiling and breathing normally. We are very proud of him!

“Ciaran will continue to need regular follow up by us. This is so we can both make sure he is ok, and also learn what to expect for the next patient who needs this innovative therapy. The treatment offers hope to many whose major airways were previously considered untreatable or irreplaceable. We will continue to work with our colleagues in regenerative medicine throughout the world to ensure we can continue to improve both the science and treatment options.”

from http://www.ich.ucl.ac.uk/pressoffice/pressrelease_00852

One in every 20 Americans over the age of 50 suffers from something called, peripheral arterial disease or PAD. It can result in clogged arteries in your legs, which can cause a heart attack, if left untreated. But now there’s a new approach. Doctors using a patient’s own stem cells to clear things up. (…)

The arteries in her leg are clogged with plaque which puts her at risk for heart attack, stroke and amputation. Traditionally, doctors treat PAD with stents, angioplasties or bypasses. But now, they’re using a patient’s own stem cells to try and save her legs.

“We basically take stem cells from their hips to help grow blood vessels,” said Dr. Randall Franz of Grant Medical Center.

Doctors use a needle to remove bone marrow from the patient’s hip. The marrow goes into a centrifuge to separate the stem cells.

“When we put it in you can see it was just all red. Now we have plasma, a buff coat and stem cells,” said Dr. Tom Hankins of Grant Medical Center.

Then, doctors inject the stem cells into the patient’s leg.